Topic: glutamatergic synaptogenesis

Adult neurogenesis, the differentiation of new neurons from neural stem cells (NSCs), occurs primarily within the subventricular zone (SVZ) and the hippocampal dentate gyrus (DG). Caffeine, the most widely used psychostimulant, is a potent non-selective adenosine receptor antagonist. Though the adenosinergic system has been shown to regulate adult brain plasticity, caffeine impact on postnatal neurogenesis and synaptogenesis remains elusive. Thus, the main goal of this work was to dissect caffeine effects on the differentiation and maturation of postnatal NSCs into neurons.Our results indicate

The significance of transient neuropeptide expression during postnatal brain development is unknown. Here, we show that galanin expression in the ventrobasal thalamus of infant mice coincides with whisker map development and modulates subcortical circuit wiring. Time-resolved neuroanatomy and single-nucleus RNA-seq identified complementary galanin (Gal) and galanin receptor 1 (Galr1) expression in the ventrobasal thalamus and the principal sensory nucleus of the trigeminal nerve (Pr5), respectively. Somatodendritic galanin release from the ventrobasal thalamus was time-locked to the first post