ePoster · Neuroscience
Stefanie Chambers, Haniye Shayeste, Philipp Lazen, Matthias Tomschik, Jonathan Wais, Lukas Hingerl, Bernhard Strasser, Lukas Haider, Gregor Kasprian, Tatjana Traub-Weidinger, Christoph Baumgartner, Johannes Koren, Katharina Moser, Florian Mayer, Martha Feucht, Christian Dorfer, Ekaterina Pataraia, Wolfgang Bogner, Siegfried Trattnig, Karl Rössler, Gilbert Hangel · FENS Forum 2024
Epilepsy, a debilitating illness characterized by seizures, often proves resistant to medication necessitating surgical intervention. Advanced MRI techniques, notably 7T MRI, can offer improved lesion detection. However, patients without structural abnormalities pose a particular challenge. In such cases, 7T Magnetic Resonance Spectroscopy Imaging (MRSI) may prove beneficial in identifying subtle metabolic alterations though higher spectral resolution, allowing the separation of metabolites with overlapping resonance frequencies such as glutamate and glutamine, key metabolites in excitatory pr
ePoster · Neuroscience
Julien Claron, Camille Giacometti, Sameer Manickam, Valentine Morel-Latour, Charles R.E. Wilson, Franck Lamberton, Céline Amiez, Fadila Hadj-Bouziane, Jérôme Sallet · FENS Forum 2024
Transcranial ultrasound neuromodulation (TUS) is a fast growing non-invasive brain stimulation method allowing reversible and local perturbation of the neuronal activity in superficial but also deep-brain structures. Although TUS efficiency has been shown at the circuit and behavioral levels, its precise impact on the neuronal tissue remains a subject of ongoing investigation. Using resting-state fMRI (rs-fMRI) and MRI spectroscopy (MRS), we characterized both the functional and metabolic effects of TUS on a subcortical structure, the amygdala.In two anaesthetized non-human primates, We select
ePoster · Neuroscience
Hyun Joon Kim, Jae Soon Kang, Ji Hyeong Baek, Hye Jin Chung, Dong Kun Lee, Sang Won Park · FENS Forum 2024
Tyrosine (Y), a non-essential amino acid, is synthesized de novo from phenylalanine and converted into L-DOPA in mammals. In the brain, ROS and RNS are increased both in acute and chronic stress conditions, leading peroxynitrite (PN) production. PN can attack Y residues of functional proteins and turn off their normal functions by nitration, called Y-nitration. Under chronic immobilization stress (CIS), glutamine synthetase (GS) activity is decreased without expression change and the decrement of glutamine (Gln) and glutamate (Glu) is found in the prefrontal cortex (PFC), which results in low-