Topic: glycinergic neurons

The trigeminal system plays a crucial role in processing somatosensory information, and its modulation is crucial for maintaining sensory homeostasis. This study investigates the inhibitory modulation of trigeminal somatosensory responses by the locus coeruleus (LC), a key brainstem nucleus that plays a critical role in many cognitive and physiological functions. Previous electrophysiological investigations have revealed a diminished ability of the LC to inhibit somatosensory responses in the caudal nucleus of the trigeminal nerve (Sp5C) of diabetic mice. The administration of noradrenaline ag

Interoception, the process through which afferent information reaches the brain to report the body's physiological state, is a critical element in adapting responses to potential threats. Cardiac interoceptive information has been shown to play a crucial role in these adaptive defensive processes. Neuronal circuits within the periaqueductal grey (PAG) play a pivotal role in controlling heart function, yet it remains unknown how PAG circuits process interoceptive signals as part of a defensive reaction to threats. Employing trans-synaptic retrograde tracing, we demonstrate that glycinergic neur