Topic: glycinergic synapses

Glycinergic synapses between the medial nucleus of the trapezoid body (MNTB) and the lateral superior olive (LSO) are involved in sound source localization. These synapses can reliably transmit inhibitory signals, even during minutes of high-frequency activation. Glycine transporter 2 (GlyT2) is involved in glycine reuptake from the synaptic cleft into MNTB axon terminals. Loss of GlyT2 reduces the synaptic transmission but does not lead to a complete failure (Brill et al 2021). The resilience suggests the presence of another glycine source. Here we investigated the contribution of Asc1, a hig

Glycine receptors (GlyRs) are crucial for the balance of excitation and inhibition in the mammalian spinal cord and brain stem. They belong to the superfamily of Cys-loop receptors and form pentameric ligand-gated chloride channels consisting of postsynaptic αβ heteromers or α homomers located extrasynaptically and at presynaptic membranes. Presynaptic GlyRs trigger depolarizing chloride currents upon activation by glycine spill-over.Autoantibodies (aAbs) against GlyRs are associated with the autoimmune disease Stiff Person Syndrome but also frequently found in patients with focal epilepsy. Lo