Topic: glyphosate

The widespread use of herbicides, including glyphosate (Gly), is thought to represent a potentially underestimated risk to human health. The putative absence of the known direct target molecular pathway of Gly in mammalian cells has assured its safety and EFSA established the acceptable daily intake (ADI) dose for humans at 0,5 mg/kg body weight. However, very little is known about Gly neurotoxicity at this dosage, especially on intricate mechanism such as the communication between brain cells. Astrocytes contribute to neuron maturation, survival, and modulation of synaptic activity also throu

The gut microbiota plays a crucial role in maintaining the physical and mental well-being of the host. It is influenced by diverse factors, including pesticides. Glyphosate, a globally used herbicide, is understood to be harmless to humans as it targets the shikimate pathway, which is absent in animal cells. However, this idea is now being challenged as research suggests that glyphosate may negatively affect the pathway in microorganisms residing in the gut, such as gut bacteria, which could have an impact on the host. Former research has tested either high dose exposure for toxicological effe

Glyphosate (Gly)-based herbicides (GBH), which are widely used worldwide, work by inhibiting the enzyme enolpyruvylshikimate-3-phosphate synthase, in the shikimate pathway, which functions in plants but not animals. Long-term exposure to GBH can cause toxic effects to the nervous system by affecting neurotransmitter expression, oxidative stress, anxiety, learning and memory impairments. Though Gly safety studies are still ongoing, little is known about the mechanistic processes underlying Gly neurotoxicity. Remarkably, few studies examined how the acceptable daily intake (ADI) dosage affects n