Topic: Go/No-Go task

Animals flexibly adjust their behavior to adapt to environmental changes. Mice excel at recognizing odorants in complex sensory conditions; however, little we know about: (1)how sudden changes in stimulus contingency modify odorant representations and (2)how changes in odorant representations causally relate to behavioral adjustments. The olfactory bulb(OB) relays odor-triggered information to higher olfactory areas, including the piriform cortex(PCx). The PCx receives input from association areas(e.g., orbitofrontal cortex) and sends dense feedback that selectively modulates one of the OB out

A fundamental question in systems neuroscience is how populations of neurons represent sensory, motor, and cognitive variables. Yet how these neural representations evolve over slow timescales is not well understood. Recent work has proposed using tensor decomposition methods to identify low-dimensional latent dynamics without requiring trial-averaging (tensor component analysis; TCA). This approach assumes that the data tensor can be described as a sum of components with fixed neural weights and temporal dynamics that vary over trials only in amplitude. However, recent evidence suggests that

Perceptual decision-making involves interpreting external stimuli and selecting the most appropriate response. Success depends on cognitive control, which includes processes like attention, working-memory, and inhibitory control regulated by differential responses of fronto-parietal networks. However, the effects on behavior and neural activity of mental fatigue induced by sustained cognitive control are still unclear. Here we show that sustained cognitive load alters cortical dynamics, leading to faster, automatic responses and hence to an increased error rate. We acquired continuous hd-EEG d

Understanding the impact of forgetting is crucial in neuronal systems, particularly in how it affects the remodeling of neuronal circuitry. In this study we explore the role of forgetting in the context of reversal learning in mice, complemented by a simulated analysis of synaptic remodeling in a recurrent neural network.In our experiment, mice were trained to discriminate between two stimuli in a go/no-go task, followed by a retention test after intervals of either 2 or 16 days. This phase was succeeded by reversal learning, where the stimulus contingencies were switched. We observed that mic

Previous research based on rodent models suggested that motor-related prefrontal areas mediate diverse functions including motor planning and cognitive functions such as decision-making, and also their flexible expression. However, whether neurons in these areas that mediate such functions are segregated populations or largely the same population are not clear. To address this question, in this study, we trained mice to perform distinct cognitive and motor task under head fixation while layer 2/3 (L2/3) neurons in the target area are imaged under multi-photon microscopy. In the cognitive task,