Topic: Golgi-cox staining

Temporal lobe epilepsy (TLE), the most common form of DRE, is associated with enhanced glutamate receptor-mediated hyperexcitability in the temporal lobe structures. The mechanism of regulation of aberrant glutamatergic activity in TLE is still elusive. Sema 3F regulates the AMPA receptor surface expression in post-synapse. In this study, we investigated the contribution of semaphorin3F (SEMA 3F) to glutamatergic synaptic activity in TLE rats' hippocampus and anterior temporal lobe (ATL). synaptic transmission in the hippocampus and ATL. Golgi-Cox staining was conducted to visualize alteration

Serotonergic psychedelics are emerging as alternative therapies for treatment-resistant depression; however, their hallucinogenic effects may limit their widespread clinical use. Second-generation psychedelics, which lack hallucinogenic effects, are a promising alternative. 2-Bromo-LSD (2-Br-LSD/BETR-001) is an LSD derivative with 5-HT2A partial agonist activity that lacks hallucinogenic effects. Thus, 2-Br-LSD may represent a possible novel therapeutic for treating neuropsychiatric diseases. We assessed the effects of 2-Br-LSD on stress-coping behaviour in mice, using the forced swim test, an

De novo gain-of-function mutations in Cav1.3 voltage-gated L-type calcium channels (CACNA1D gene) confer a high risk for neurodevelopmental and neuropsychiatric diseases. However, how these mutations affect neuronal function remains elusive. Previously, we demonstrated that the autism-associated A749G mutation induced an overall dendritic spine elongation in transfected mouse hippocampal neurons. This study aimed to investigate the influence of A749G Cav1.3 channels on the dendritic branching, spine density, and neuronal soma size in the brains of heterozygous (HET) A749G knock-in mice. To do