Topic: gonadotropin-releasing hormone

Reproductive disorders are associated with neuroendocrine dysregulation in the hypothalamic-hypophysis-gonadal (HHG) axis, which can result from a defective production and action of the neuropeptide gonadotropin-releasing hormone (GnRH), the master regulator of reproduction. We have previously shown that SELENOT, a new thioredoxin-like selenoprotein highly expressed in endocrine and neuroendocrine cells, plays a role in hormone secretion. However, whether SELENOT is involved in neuroendocrine regulatory mechanisms that impinge on vital functions such as reproduction, is totally unknown. We fou

Down syndrome (DS) patients who show mental retardation also present acquired anosmia, i.e., the loss of odor detection. At the present time, no viable treatment exists for cognitive and olfactory deficits in DS. Interestingly, the ability to reach puberty and become fertile is also affected in these patients. An intriguing candidate, whose absence could mediate most of these phenotypes, is the gonadotropin-releasing hormone (GnRH), the neurohormone controlling reproduction. However, whether GnRH plays a role in the age-related cognitive decline in DS is unknown.We showed in Ts65dn mice, a wel