Topic: graph analysis

Spatiotemporal patterns of neuronal activity are hypothesized to be essential for information processing in the brain. They suggest the existence of cell assemblies, groups of co-active neurons that represent a distinct cognitive unit, potentially related to specific behaviors or representations. Conventionally, cell assemblies are defined by strong structural connections, such that the stimulation of a portion of its members should transiently activate the entire assembly. Their exact composition and computational role, however, have yet to be fully clarified. We present the detection of spik

Poor patient outcomes in resective epilepsy surgery remain an area of clinical concern. Regardless of epilepsy type, a third or greater of drug-resistant epilepsy (DRE) patients who undergo resection do not report seizure freedom at a two-year follow-up. One of the likely causes is that current methods for identifying which tissue to resect are subjective and potentially inaccurate. Much of resective surgery planning is based on identification of initial ictogenic tissue--the seizure onset zone (SOZ). However, complete resection of the SOZ, as currently identified, is a poor prognosticator of