Unified C. elegans Neural Activity and Connectivity Datasets for Building Foundation Models of a Small Nervous System
Quilee Simeon, Anshul Kashyap, Konrad Kording, Ed Boyden · Bernstein Conference 2024
We present a comprehensive dataset of neural activity, compiled from 11 neuroimaging experiments in the nematode worm C. elegans. These source datasets, while collected under different experimental protocols, all measure neural activity via changes in calcium fluorescence in labeled subsets of the hermaphrodite worm’s 300 neurons. Our contribution is to standardize these disparate datasets into a unified framework including ordering the neural data from labeled neurons consistently, resampling traces to a common timestep, and including a feature mask to indicate which neurons were labeled in e