Topic: graph Laplacian

Brain activity lies on a very complex network. This complexity is multiple but a prominent one is the non-linear and multi-factorial interaction between its nodes. In the specific case of Parkinson's disease (PD), the brain loses dopaminergic neurons in the substantia nigra compacta (SNc). Highly involved in the basal ganglia-cortex-thalamus-cerebellum (BG-Ctx-T-Cb) network, the main role of dopamine (DA) is in learning, decision-making and motor control, as manifested in the PD symptoms such as rigidity, slowness of movements, tremor and poor behavioural flexibility. Following DA loss, the un