Seminar · Developmental Neuroscience
Playing fast and loose with glutamate builds healthy circuits in the developing cortex
Chris Dulla · Tufts University
Wed, Feb 17, 2021 · 16:00 UTC
The construction of cortical circuits requires the precise formation of connections between excitatory and inhibitory neurons during early development. Multiple factors, including neurotransmitters, neuronal activity, and neuronal-glial interactions, shape how these critical circuits form. Disruptions of these early processes can disrupt circuit formation, leading to epilepsy and other neurodevelopmental disorders. Here, I will describe our work into understanding how prolonged post-natal astrocyte development in the cortex creates a permissive window for glutamate signaling that provides to