Topic: Growth-factor receptor bound protein 10

Growth-factor receptor bound protein 10 (GRB10) is a signal adapter protein encoded by an imprinted gene, with roles in growth control, cellular proliferation, and insulin signalling. Grb10 has a unique, tissue-specific imprinted expression; the paternal copy being expressed in the CNS, whereas the maternal copy is expressed in most other adult tissues in the mouse and human. Nevertheless, although it is critical for normal behaviour in the mouse, the role of paternal Grb10 in brain growth has yet to be established. Here we investigate the brain-growth in mice lacking paternal Grb10 (Grb10+/p)