Topic: growth factor signaling

Glioblastoma (GBM) patients have a poor prognosis due to glioblastoma stem cells (GSCs) that resist current treatments. Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins, particularly Lrig1, play a role in growth factor signaling in various stem cells. In this study, the function of Lrig1 in glioblastoma stem cells was investigated using gain- and loss-of-function experiments. Removing Lrig1 in cultured GBM stem cells increased proliferation and reduced quiescence, while overexpression of Lrig1 enhanced quiescence and reduced proliferation. Mice transplanted with Lrig1-defic

Introduction:The glycoprotein clusterin (CLU) plays a pivotal role in vital cellular functions, including cell proliferation and DNA damage repair. Its frequent overexpression in tumor cells, particularly in gliomas, positions it as a promising therapeutic target. This study aims to investigate the impact of CLU dysregulation on glioma cell lines and explore its therapeutic potential. Methods:Two human astrocytic cell lines, CCF-STTG1 astrocytoma cells, and SV-40 immortalized normal human astrocytes, were utilized in our investigation. CLU expression was suppressed using transient siRNA transf