Topic: hair cells

The sense of orientation in space is crucial for survival and navigation in the environment. The brain derives spatial orientation from (1) self-motion signals originating in the vestibular system of the inner ear and (2) visual signals encoding orientation relative to external landmarks. Previous studies in animal models have shown that spatial orientation is compromised after vestibular lesions, but the relationship between partial lesions and the degree of functional impairment has not been established.In the present study, navigation and spatial orientation capacities were tested in a modi

Background: ATOH1 is recognized as a crucial transcription factor for hair cell differentiation. Although Atoh1 expression has been documented in a subset of developing spiral ganglion neurons, its specific role in neuronal development remains to be elucidated.Methods: We generated a novel conditional deletion model (Atoh1Cre-Isl1CKO) targeting Isl1 in the inner ear. Immunohistochemistry was used to examine morphological and cellular changes in the inner ear. Additionally, we assessed the hearing function of Atoh1Cre-Isl1CKO mutants compared to littermate control mice using auditory brainstem