Topic: hippocampal adult neurogenesis

Yueju, a Chinese traditional herbal medicine formula, has a rapid antidepressant action. We have previously identified two active ingredients from Yueju: two iridoids, geniposide (GM) and shanzhiside methyl ester (SM). Only co-treatment (GS) with GM (44 mg/kg) and SM (4.7 mg.kg) elicits synergistic rapid antidepressant action by activating polypeptide (PACAP) activity and its associated CaMKII–BDNF signalling the hippocampus. We further investigate whether chronic treatment with GM and SM are effective in eliciting antidepressant effects via enhancing hippocampal adult neurogenesis. Two mouse

Aging produces in brain a progressive oxidative process and neuroinflammation that deteriorates cognition. These brain dysfunctions provoke high economic and social costs to developed societies. For this reason, the search for treatments to prevent cognitive deficits associated with aging is a priority. Previous results suggest that STX64, a steroid sulfatase (STS) inhibitor, improves cognition in neurodegenerative diseases. In this work, we have designed cellular (immunohistochemistry), molecular (qPCRs with primers of inflammatory markers and cellular populations) and behaviour (mainly, obje