Topic: hippocampal CA1

Brain-computer interfaces (BCIs) are a powerful tool in both clinical applications and basic science research. Traditionally, BCIs rely on electrical signals collected by electrode arrays, which usually suffer from instability due to electrode movements and cell loss [1]. Recent approaches to address this issue continuously update BCI decoders [2]. By reliably identifying the same cells over days, using $Ca^{+2}$ imaging as BCI input may circumvent these limitations, and enable simultaneous recording from large neuronal populations over extended periods. Nonetheless, $Ca^{+2}$ imaging data typ

Introduction: Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT is activated in vitro by Hebbian-like conjunction of pre- and postsynaptic activities, which promote the formation of dendritic filopodia via proteolytic cleavage of the proteoglycan agrin. Aims: 1) to examine the functional importance of NT for synaptic plasticity, learning, and extinction of memory in juvenile and matured mice, and 2) to evaluate the therapeutic potential of an NT-generated fragment of agrin, agrin-22. Methods: 1-month-old “Juvenile” NT−/−