Topic: hippocampal CA1 synapses

BDNF mediates long-term potentiation (LTP) of hippocampal CA1 synapses by a translation-dependent mechanism. A master regulator of local protein synthesis at the synapse is fragile-X-messenger ribonucleoprotein (FMRP), however it is unclear to what extent FMRP mediates the effects of BDNF on the synaptic proteome. In this work we investigated whether FMRP regulates the synaptic content of GluN2B-containing NMDA receptors (NMDAR) with implication in synaptic plasticity. Acute hippocampal slices were prepared from WT and Fmr1y/- mice, and LTP was triggered with five theta-bursts, which induces B

Short-term plasticity (STP) is the neuronal substrate for modification of the efficiency of synaptic transmission in the timescale of milliseconds to seconds. STP renders synapses the ability to process and integrate inputs which in-turn controls information flow and processing in networks. Our work explored the diversity in STP of hippocampal CA1 synapses and the summation of multiple inputs during STP in a CA1 neuron with balanced excitation and inhibition. We performed invitro experiments on the CA3-CA1 network in acute hippocampal slices from mice expressing channelrhodopsin specifically i