Topic: hippocampal CA2

Social memory, one's ability to recognize and remember experiences with other conspecifics, consists of several discrete psychological processes. These include the ability to rapidly detect whether an individual is novel or familiar (“I know that person, but from where?”) and the recollection of an individual’s specific identity and the associated set of past experiences (“ah, we met at COSYNE last year”). These processes have conflicting demands and requirements. Familiarity is an abstract concept that can readily generalize to any individual in any context. In contrast, social episodes consi

Alzheimer’s disease (AD) early stages are characterized by amyloid beta oligomers (oAβ) toxicity in the hippocampus, leading to its dysfunction. Previously, we characterized a non-transgenic mouse model of early amyloidosis by a single intracerebroventricular (icv.) injection of oAβ1-42, that showed deficient hippocampal-dependent memory and synaptic plasticity impairment in the CA1–CA3 synapse regardless the sex. Social memory impairments have also been described in AD. However, neuronal oscillatory activity in hippocampal CA2 subfield, a region that plays a crucial role in the formation and

Disturbances in the neuronal activity of the hippocampal CA2 subregion have been shown to result in impaired social memory in rodents. However, the current assessment of behavioural role of CA2 within the circuit of cognition relies on classical tests, presenting only a snapshot of the behaviour of subjects. As both clinical and preclinical data have revealed a relevance for CA2 in psychiatric disorders such as schizophrenia, it is crucial to uncover the effects of CA2 E/I imbalance in more natural social environments over longer periods of time. Furthermore, gaining a deeper understanding of

Sleep is essential for memory formation and consolidation, and sleep loss is associated with cognitive decline. The CA2 subregion of the hippocampus is involved in social memory and plays a critical role in altering brain activity and memory performance. Despite the crucial role of hippocampal CA2 in memory, how sleep influences social memory remains relatively unexplored. Our aim was to investigate whether and how sleep loss influences the CA2 region in terms of synaptic plasticity and social memory in mice. We conducted field electrophysiology, Western blot analysis, and behavioral studies.