ePoster · Molecular Neuroscience
Distinct Fos- and Npas4-mediated synaptic plasticity crucial for memory consolidation
Douglas Feitosa Tomé, Meizhen Meng, Xiaochen Sun, Sadra Sadeh, Yingxi Lin, Claudia Clopath · COSYNE 2023
Sat, Mar 11, 2023
Experiences are encoded in sparse neuronal ensembles that can be defined by the transcription activation of immediate-early genes such as Fos and Npas4. The Fos+ and Npas4+ neuronal ensembles within an engram have been reported to recruit distinct synaptic plasticity mechanisms. However, it remains unknown whether and how Fos- and Npas4-mediated synaptic plasticity support memory consolidation. Here we provide experimental and computational evidence that Fos+ and Npas4+ neuronal ensembles coordinate different excitatory and inhibitory synaptic plasticity mechanisms to promote memory consolidat