Topic: hippocampal dysfunction

Parkinson’s disease (PD) often results in hippocampal dysfunction, which leads to cognitive and emotional challenges and synaptic irregularities. This study attempted to assess behavioral anomalies and identify differentially expressed genes (DEGs) within the hippocampus of a hemiparkinsonian rat model to potentially uncover novel genetic candidates linked to hippocampal dysfunction. Striatal 6-hydroxydopamine (6-OHDA) infusions were performed unilaterally in the brains of adult SD rats, while dopaminergic impairments were verified in rats with 6-OHDA-lesioned striata. RNA sequencing and gene

Alzheimer's disease (AD) is a complex and multi-factorial disorder, leading to progressive cognitive impairment. Hippocampal dysfunction plays a crucial role in spatial memory deficits in AD. However, the precise alterations in hippocampal neuronal activity in AD during memory-guided behaviour remain unclear. To study this, we introduced a novel behavioural paradigm for assessing spatial memory in head-fixed mice during a continuous alternation task, which can be used in conjunction with two-photon calcium imaging to investigate changes in hippocampal network activity, including spatial and tr

Early Alzheimer’s disease (AD) stages (that start even decades before clinical disease onset) are characterized by hippocampal dysfunction induced by amyloid-β oligomers (oAβ). Indeed, we have recently characterized hippocampal-dependent memory encoding and retrieval deficits and synaptic plasticity impairments in a non-transgenic mice model of early AD amyloidosis. Some protein changes underlying those deficits have been previously studied, but the spatial distribution within the hippocampus, and the possible sex dimorphism, has not been investigated before. Since each hippocampal part has cl