Topic: hippocampal excitability

The brainstem locus coeruleus (LC) is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline (NA) is a neuromodulator involved in the regulation of excitability of brain networks. In this study, we investigated whether chemogenetic activation of the LC is able to induce hippocampal noradrenaline release and affects hippocampal excitability.Male Sprague Dawley rats (n=8) were injected with the viral vector CAV2-PRSx8-hM3Dq in the LC for expression of hM3Dq, which allows chemogenetic LC activation upon systemic injection with deschloroclozapine (DCZ). Rats w

The adenosine A1 receptor (A1R) is a promising therapeutic target in epilepsy by mediating neuronal inhibition. In this study, we investigated whether A1R signaling is still functional in the intrahippocampal kainic acid (IHKA) mouse model for temporal lobe epilepsy (TLE). Moreover, we evaluated the feasibility of spatial selective inhibition of specific hippocampal subregions through photopharmacology. Electrically evoked field postsynaptic potentials (fPSPs) were recorded in the CA1 and DG of acute hippocampal slices. The effect of adding 40 nM of the A1R agonist N6cyclopentyladenosine (CPA)

The sleep stage in mammals consists of rapid eye movement (REM) sleep and non-REM (NREM) sleep. Each sleep stage has its own electrophysiological characteristics. For example, REM sleep is characterized by ponto-geniculo-occipital (PGO) waves in the brainstem and theta waves in the hippocampus, and NREM sleep by sharp wave-ripples (SWRs) in the hippocampus. These are thought to be important for memory processing. To date, however, their contributions to memory have been studied independently, and no studies have addressed the relationship between hippocampal neural activities and PGO waves. PG

To comprehend the brain’s dynamic physiology, we must understand the mechanisms underlying neuronal excitability, crucial for neurons’ electrical activation during synaptic communication. Of particular interest is controlled potassium current leakage via two-pore domain potassium channels which finely modulate the intrinsic excitability of neurons. TRESK, the latest discovered channel of the K2P family, has a well-characterized pivotal role in nociception. Intriguingly, it also exhibits widespread expression throughout central nervous system, yet its function within the brain has remained unex