Topic: hippocampal glutamatergic neurons

The stress response serves as a protective mechanism to address daily challenges, yet it's crucial for it to cease when the threat subsides, as prolonged stress engagement links to higher vulnerability to neuropsychiatric disorders.Lysine Specific Demethylase 1 (LSD1) is an epigenetic enzyme participating in the CoREST/HDAC2 corepressor complex regulating neuronal plasticity-related gene transcription. In the mammalian brain, LSD1 activity is modulated by its neurospecific splicing isoform neuroLSD1, lacking co-repressive activity as long as the ability to recruit corepressor partners. Numerou

Stress-induced alterations in cognitive functions are documented to be mediated by corticosteroid hormones and hence mineralocorticoid (MR) and/or glucocorticoid receptor (GR) activation. Moreover, recent evidence underscores the pivotal role of the endocannabinoid system (ECS) as a modulator of stress responses including the impact of corticosteroids on diverse memory processes. However, the precise mechanisms governing corticosteroid-induced impairment of novel object recognition (NOR) retrieval are yet unknown. The present study aims at elucidating the intricate interactions between cortico