Topic: hippocampal interneurons

Hippocampal Interneurons are heavily myelinated but show differences in composition/distribution and myelin function. Contactin-2 (CNTN2 or TAG-1), an adhesion molecule of the immunoglobulin superfamily, expressed in glia and axons, organizes the juxtaparanodal region of myelinated fibers and clusters voltage-gated potassium channels under the myelin sheath. CNTN2 has a dynamic spatial and temporal expression and is implicated in migration during development as well as in neuropathology (multiple sclerosis, AD). We have shown that a significant population of hippocampal GABAergic interneurons

Cognitive impairment and disturbed excitatory-inhibitory balance in the brain have been linked to severe psychiatric illnesses such as schizophrenia, affective disorders, and autism spectrum disorders. Erythropoietin (EPO) may have a role in mitigating them by rectifying hippocampal transcriptional networks and synaptic architectures of pyramidal lineages when administered to juvenile mice. How EPO involves interneurons to rebuild synapses is an impending puzzle. After examining ~12,000 single-nuclei transcriptomic data, we generated a comprehensive molecular atlas of hippocampal interneurons,