Topic: Hippocampal networks

Hippocampal networks link temporally contiguous memories through spiking sequences that encode sensory cues (external world) and time between them (internal representations), constructing ‘memory-maps’ of related experiences. It was recently shown that such sequences combine particularly stable representations of sensory cues with highly dynamic, learning- dependent temporal-codes. This combination of stability and flexibility allows linking fixed elements of the external world across variable time intervals. But how does feedback inhibition by parvalbumin- (PV) and somatostatin-expressing (SO

N6-methyladenosine (m6A) methylation, the most prevalent eukaryotic mRNA modification, is enriched in the mammalian brain and the synaptic transcriptome. m6A methylation is dynamically regulated by enzymes called m6A writers (METTL3/14) and erasers (FTO), that are present in distal neuronal processes. Although recent studies link dynamic m6A methylome changes during synaptic plasticity to memory consolidation, the exact mechanisms in neuronal circuits remain unclear. This study investigates m6A methylation effects on synaptic transmission and plasticity within hippocampal networks, utilizing p