Topic: Homer1a

Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased oscillation of clock negative regulatory loop, as well as a phase shift of Bmal1 expression in the medial prefrontal cortex (mPFC) of a mouse model of depression (depression-like behavior and anhedonia induced by daily 10 min swim sessions for 5 consecutive days). Selective disruption of mPFC clockwork with viral Bmal1KO in CaMK2a excitatory neurons blocks the development of depressive-like phenotype in our model of depre

The retrosplenial cortex (RSC) and hippocampus support the encoding, storage, and retrieval of different aspects of associative experience. In the hippocampus, learning and updating information about the content details of space triggers long-term depression (LTD) (doi: 10.3389/fnbeh.2022.806356) . Here we used fluorescence in situ hybridization (FISH) explore to what extent this kind of spatial content learning triggers somatic immediate early gene (IEG i.e. Homer1a) expression in the cornus ammonis and RSC, as an indication of active storage of learned experience. Adult rats explored novel s