Topic: human hippocampus

Goal-directed navigation is a complex cognitive process that requires a precise relational representation of the spatial environment and its associated rewards. This process enables agents to choose optimal paths that maximize long-term rewards, which is essential for the survival of both humans and animals. While hippocampal place cells are traditionally linked to representing spatial location information, rodent studies have shown that they also exhibit predictive coding and reward-dependent place fields, suggesting their role extends beyond spatial representation. The Successor Representati

Human brain function results from continuous activity flowing through specific cells, guided by specific synaptic arrangements. Therefore, determining the architecture and properties of functioning microcircuits is fundamental to understand the brain’s action. However, our current knowledge of human microcircuits is extremely limited, and relies heavily on assumptions from rodent research. Using tissue resected from 13 temporal lobe epilepsy patients, we perform multicellular patch-clamp based microcircuit analysis (n=80 recordings) to characterize synaptic connectivity in the human hippocampa