Topic: Huntingtin gene

Huntington's Disease (HD) is a monogenic and neurodegenerative disorder cause by an abnormal amount of CAG repeats in the exon 1 of the huntingtin gene, responsible for numerous transcriptional and cellular process dysfunctions, leading to neuronal death. HD mainly targets the medium spiny neurons of the striatum and more broadly the corticostriatal pathway, but other brain areas, such as the hippocampus, are also affected at more advanced stages of the disease. These deregulations are responsible for a triad of symtoms, consisting in cognitive and psychiatric symptoms that occur prior to the

Huntington’s disease (HD) is a hereditary neurodegenerative disorder marked by progressive motor and cognitive decline caused by a mutation in the huntingtin gene. Emerging research implicates the immune system and inflammation in HD pathogenesis. Recent investigations reveal immune cells and lymphatic networks within the meninges, challenging their conventional role solely as a protective CNS barrier. Meningeal immune cells are increasingly recognized for their role in normal brain function and various neurological disorders. However, investigations into meningeal immunity in the context of H