ePoster · Neuroimmunology
Extracellular matrix and microglia interactions in stroke recovery
Egor Dzyubenko, Dirk M. Hermann · FENS Forum 2024
Stroke remains a leading cause of long-term disability, with effective therapies hampered by an incomplete understanding of brain recovery mechanisms. Emerging evidence indicates that the interactions between the brain extracellular matrix (ECM) and glial cells1 critically contribute to post-stroke neuroplasticity and can help promote stroke recovery.We investigated the role of perineuronal nets (PNNs), facet-like ECM layers surrounding fast-spiking interneurons, in neurological recovery following focal cerebral ischemia in mice. Using superresolution stimulated emission depletion (STED), stru