Topic: hyperlocomotion

Our environment is polluted with plastic waste, wherein the degradation leads to the formation of micro and nanoplastics (NPs). These plastic particles contaminate water, soil, air, and food, exposing humans throughout their lives. Although NPs are detected in the human body, such as in blood, feces, and placenta, their potential impact on human health remains poorly understood. Moreover, the developing brains of fetuses and children may be sensitive to these molecules, potentially leading to functional impairments and altered behavior. Our study investigates the impact of chronic, low-dose ex

Tremendous progress has been made in treating psychotic disorders, although available pharmacotherapy remains insufficient. Symptoms related to reality misinterpretation are key for diagnosis but challenging in preclinical research. In humans, the Mirror-Gazing test has been employed to examine abnormal self-experience and to predict a risk of schizophrenia manifestation. The lack of corresponding animal methods impedes the development of novel drugs for early antipsychotic interventions. We established a task to evaluate anomalous subjective experience in rats using a mirror test. Initially,

NMDA receptor antagonists, such as MK801, produce hyperlocomotion and affect the dopamine (DA) system by increasing ventral tegmental area (VTA) activity and enhancing DA release in many regions of the rat brain. NMDAR antagonists also enhance the power of high-frequency oscillations (HFO) in cortical and subcortical areas. The olfactory bulb (OB), a generator of NMDAR-enhanced HFO, contains DA receptors (D1R/D2R) and periglomerular DA neurons. However, the role of DA in the OB in the modulation of MK801-enhanced HFO and locomotion is unknown. Selective DA agonists (SKF38393, quinpirole) and a