ePoster · Neuroscience
Joelma Alves Lucio, Thiago Ângelo Smaniotto, Francisco Daroda, Regina Andressa Caetano de Souza, Brenda Guisolfo Machado, Esthefany Maria Rodrigues da Rosa, Laura Piloneto Lima Hoefel, Bruna Lise Tusset, Gabriella Aparecida Toledo Campos, Eduardo da Silva Santos, Giuliana Petiz Zugno, Carla Dalmaz · FENS Forum 2024
Early adversities can shape adult behavior, and the early developmental period is an important temporal window for the maturation of brain structures. Potential different phenotypes resulting from environmental modifications during development can eventually impact susceptibility to psychiatric disorders and contribute to the emergence of eating disorders, substance abuse, as well as alter cognitive processes and memory formation. Maternal separation (MS) is a model of early stress that leads to long-lasting changes in the responsiveness of the hypothalamic-pituitary-adrenal axis, as well as b
ePoster · Neuroscience
Clémence Viguier, Marie Bailly, Julie Thevenin, Laura Guiraud, Jean-paul Motta, Marion Allaoua, Virginie Noirot, Pierre Etienne, Nathalie Vergnolle, Bruno Guiard, Lionel Moulédous · FENS Forum 2024
Modification of the olfactory system can dramatically influence emotion and it is well accepted that mice with olfactory impairments develop pseudo-depressive symptoms (Yuan. M. et al, 2020) and microbiota dysregulation (Shuai-Ming Zhu et al, 2024). On this backdrop, our research is currently focusing on the therapeutic potential of exploiting the olfactory system in mood-related disorders. Different odors can exert anxiolytic and/or antidepressant-like effects in several depression models. To better understand the functional relationships between odors, emotion, microbiota and gut physiology
ePoster · Neuroscience
Minji Kim, Minseok Yoon, Suengmok Cho, Min Young Um · FENS Forum 2024
Rice bran extract (RBS) possesses a wide range of biological properties; however, its potential antidepressant effects and molecular mechanisms remain unclear. This study aimed to investigate the antidepressant effects of RBS in a mouse model of chronic stress (CS)-induced depression and anxiety and elucidate the underlying molecular mechanisms. Mice exposed to CS were administered RBS at different doses (250, 500, and 1000 mg/kg/body weight) for 5 weeks. The results demonstrated that RBS significantly improved depressive and anxiety symptoms, as evidenced by increased sucrose preference and r
ePoster · Neuroscience
Alessandra Berry, Barbara Collacchi, Letizia Giona, Eleonora Tammaro, Vincenzo Coppola, Antonio Volpicelli, Francesca Cirulli, Mario Luciano · FENS Forum 2024
Bipolar disorder (BD) patients have shown increased circulating levels of pro-inflammatory cytokines and cortisol and decreased levels of Brain-Derived-Neurotrophic Factor (BDNF) suggesting that these mediators might be involved in the occurrence of affective episodes disrupting brain plasticity. Aim of the study was to assess variations in peripheral neuroendocrine and inflammatory markers during acute phases of the disease and euthymia as possible predictors of affective episodes and as a reliable signature of the disease. BD patients were enrolled during depressive or manic/hypomanic phases