Topic: hypoxia inducible factor-1α

Neurodegenerative disorders, such as Alzheimer’s disease (AD), are the object of intense investigation due to their prevalence worldwide and the lack of an effective treatment to mitigate cognitive deterioration. This is because we still do not fully understand what triggers sporadic AD although several risk factors that predisposed disease development have been identified. Among them, genetic variants of the Apolipoprotein E (ApoE) or gene mutations in ADAM10 or TREM2 proteins have attracted particular attention, either for their prevalence and/or their relationship to glial cell function. In