Topic: Iba-1

Previous tetracycline (TC) studies hinted at its analgesic potential. We explored here it in new non-antibiotic TC derivatives. Using the formalin-induced nociceptive pain model in male adult C57⁄BL6 mice, we tested the effects of DDMC (5, 10, 20 mg.kg-1) and DDOX (10, 20, 40 mg.kg-1), non-antibiotic derivatives of demeclocycline and doxycycline, respectively. A sub-chronic treatment with 5 mg.kg-1 of DDMC remarkably reduced nociceptive pain in both phases of the test, comparable to morphine (10 mg.kg-1). DDOX was also effective but intrinsically less potent than DDMC as exerting analgesic eff

Microglial reactivity is linked with the loss of dopaminergic (DA) neurons in Parkinson’s disease (PD). In this context, we propose that calcium, potentially released by DA dying neurons to the extracellular space, may contribute provoking changes in microglial polarization.Postmortem samples from PD patients exhibited increased microglia-neuron interactions in the Substantia Nigra (SN) when compared with control individuals, indicating a polarization of microglia in this pathological scenario. Besides, MPTP-treated parkinsonian mice also revealed a significant number of polarized microglia to

Obesity is a major risk factor for metabolic and neuropsychiatric disorders. High-fat diets have been shown to trigger systemic and central inflammation, particularly in the hypothalamus. The lingual CD36 receptor plays a crucial role in oro-gustatory perception and is downregulated in individuals with obesity. NKS-3, a non-caloric high affinity CD36 agonist, exerts systemic anti-inflammatory effects by reducing pro-inflammatory cytokines; however, its potential impact on neuroinflammation is not known. C57BL/6 male mice were fed with either a high-fat (HFD) or a standard (STD) diet for 12 wee