Topic: ibuprofen

Major depressive disorder (MDD) is a widespread mental health condition affecting over 280 million people worldwide and is a major contributor to the global burden of disease. Despite selective serotonin reuptake inhibitors (SSRIs) being the first line of treatment for MDD, 30-40% of patients do not achieve remission, with chronic low-level inflammation linked to treatment resistance. This study aimed to evaluate the efficacy of the anti-inflammatory drug ibuprofen compared to the SSRI fluoxetine in a mouse model of inflamed depression. The objective was to explore whether anti-inflammatory dr

Viral infection-induced inflammation during pregnancy has been associated to malformations of the fetal brain. Microglia, the brain-resident macrophages, respond to inflammatory signals and at the same time are actively involved in various aspects of brain development. We know surprisingly little about how microglia balance the different demands during human embryonic development and which functional consequences an inflammatory environment has on neuronal organization and connectivity. Human induced pluripotent stem cells (hiPSC) provide a unique opportunity to investigate this relationship.H