Topic: ID2

Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment.Microglia, the brain's resident immune cells, play a crucial role in this environment. Glioblastoma cells canreprogram microglia to create a supportive niche that promotes tumour growth. However, the mechanismscontrolling the acquisition of a transcriptome-associated with a tumour-supportive microglial reactive state arenot fully understood. In this study, we investigated changes in the transcriptional profile of BV2 microgliaexposed to C6 glioma cells. RNA sequencing analysis revealed a signifi

Recent studies have shown that molecular programming by basic helix-loop-helix (bHLH) proteins can reactivate wiring in adult neurons. Meanwhile circuit analyses in these studies demonstrated functional circuit formation, the underlying molecular mechanisms remain elusive. Here, we used RNAseq, mass-spectrometry, and immunohistochemistry to investigate the transcriptomic and proteomic consequences of Id2 (a regulator of bHLH transcription factors) and Ascl4 (a bHLH transcription factor)-induced wiring in adult hippocampal granule cells, which lead to the formation of mainly feedback and feedfo