Topic: IL-10

Multiple sclerosis (MS) is a chronic neurodegenerative disease that is the leading cause of disability in young adults. The most severe clinical form of MS is the primary progressive (PP). We and others have shown that melatonin (MLT), improves the disease modulating the immune response in the Experimental Autoimmune Encephalomyelitis (EAE) monofasic mouse model of MS. Thus, the objective of this study was to evaluate the therapeutic use of MLT in the neuroinflammation, neurodegeneration and gut dysbiosis in the preclinical model of MS-PP, the progressive EAE (p-EAE).p-EAE was induced in 10-we

Scalp acupuncture (SA) has shown potential as a treatment for acute ischemic stroke. This study investigated the effects and mechanisms of SA in rodent stroke models using systematic review, animal experiments, and analysis of peripheral responses. Subsequent animal studies confirmed the anti-inflammatory effects of SA, showing reduced TNF-α, IL-1β, IL-6 and increased IL-10 in rat stroke brains. SA enhanced neurological outcomes, as measured by the 6-point neuroscore, cylinder test, and grip strength test. Although SA's reduction in stroke infarct area was not statistically significant, it not