Topic: IL-6R

Pleiotropic cytokine IL-6 regulates various processes in the body including neuronal functions. IL-6 can signal through its membrane bound receptor IL-6R, which associates with IL-6 signal transducer gp130 IL-6st/gp130 (classical signaling), or binds to soluble IL-6R to act on any cell that that expresses IL-6st/gp130 (trans-signaling). Alzheimer’s disease related enzyme BACE1 has critically important roles in synaptic function and cleaves IL-6st/gp130 as well as IL-6R.Therefore, we hypothesize that BACE1 could be essential for the alteration of neuron excitability and synaptic plasticity via

Interleukin 6 (IL-6), its receptor (IL-6R), with the IL-6 signal transducer gp130 (IL-6ST) are well known regulators of innate immunity but also affect neuron morphology and function. More recent evidence suggests that they also play a significant role in shaping microbiota composition and gut-barrier function (1). However, the exact pathways and mechanisms are still elusive. We therefore investigated the involvement of functional IL-6 signaling in the bilateral communication between primary afferent neurons and gut microbiota.Transgenic mice with a conditional depletion of gp130 in neurons ex