Topic: IL6

A growing body of evidence indicates a substantial role of the immune system and inflammation in the pathogenesis of Alzheimer’s disease (AD). In the current study, we investigated the effect of maternal immune activation (MIA) on AD-resembling pathological alterations in 12-month-old offspring. We also aimed to analyze whether inhibition of bromodomain and extraterminal domain (BET) proteins, the readers of the histone acetylation code, might impact these changes. In our study, we injected a viral mimetic polyinosinic-polycytidylic acid (PIC) at gestation day 17 to evoke MIA in wild-type mice

Social stress increases susceptibility to develop substance use disorders, which can be modulated by intermittent exposure to a high-fat diet (HFD). However, both HFD and stress can elevate neuroinflammation levels under specific conditions. The objective of this study was to assess the protective role of intermittent exposure to HFD on the increase in ethanol consumption induced by social stress. The neuroinflammatory response in the hippocampus and the striatum was evaluated by quantitative real-time PCR of several gene expressions. Adult male OF1 mice were exposed to the repeated social def