Topic: image-processing tools

Traditional histology relies on thin sections of small samples for studying human tissues, which limits our understanding of the complex structure and anatomical relationships of whole organs. Gross anatomy and medical imaging on the other hand lack the resolution and specificity to visualize histological structures. Tissue clearing methods are emerging as innovative solutions to transcend this constraint by revealing the spatial architecture of large tissues samples. However, making adult human organs transparent remains a challenge, given their size, density and endogenous fluorescence. We h

Neuropsychiatric disorders are prevalent diseases whose causes and mechanisms remain unknown due to its complexity. In this context, translating experimental findings from humans to the clinic represents a major challenge that new technologies are assessing. Here we propose the use of a neurohistopathology pipeline to perform systematic multiscale analysis of pathological human brains and identify the cellular, molecular and circuit underpinnings of neurodegenerative and psychiatric disorders. We have developed and adapted new tissue clearing and labeling techniques in large scale samples, whi