Topic: immediate early gene mapping

Patients with an anxiety disorder often display aberrancies in sensing the internal state of the body. Interoception is activated for example by mild hypercapnia during CO2 inhalation due to homeostatic disturbances of the body eliciting anxiety and even panic-like behaviours across species. Yet, although altered interoception is increasingly recognized as an important component of anxiety disorders, its underlying neural mechanisms remain little understood. Here, we aimed to elucidate whether trait anxiety levels affect the engagement of the anxiety network in response to CO2 challenge. Mice

Despite the pervasiveness of chronic pain worldwide, few effective strategies for long-term pain management exist. The development of new, non-addictive pain interventions hinges upon a deeper understanding of the changes in neural activity and circuitry that drive the development of chronic pain states. Recent studies have implicated the basolateral amygdala (BLA) as a critical hub in the encoding of negative valence to nociceptive information. Using immediate early gene mapping in combination with an activity-based rabies viral tracing screen, we identified several brain regions that synapse