Topic: immune cell infiltration

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that lacks effective therapeutic strategies to date. GemPharmatech (GPT) generated the GPT hSOD1 G93A transgenic mouse strain to recapitulate ALS-like phenotypes in an animal model, in support of medical research and drug development. The hSOD1 G93A mouse model carries the G93A mutation in human SOD1 gene, which is widely expressed in mice. We observed an apparent body weight decrease in 25-week-old mice. We further performed a range of behavioral tests to identify the disease onset timing in GPT hSOD1 G93A mouse model,

Clinical intervention for ischemic stroke patients is limited to the acute phase, leaving ~80% of stroke patients without effective pharmacological intervention and unsatisfactory neurological outcome. Therefore, subacute therapeutics that resolve thrombosis and inflammatory processes to support tissue recovery are urgently in need. Plasma kallikrein (PK), a member of the kallikrein-kinin-system, promotes vascular damage, inflammation, and thrombosis. We hypothesize that prolonged PK activation determines stroke severity and impairs tissue recovery. Thus, wild-type mice were subjected to 60 mi