Topic: immunotoxin

Lateralization of motor skills such as hand preference is a common trait across various species, including humans and rodents. It's well known that humans can alter their dominant hand through training, a process often associated with psychological stress and the potential for developmental issues, including language impairments. Yet, the neural mechanisms underlying the hand switching remain largely obscure. Our research delves into this phenomenon in mice, revealing that they can also alter their hand preference via corrective training. We focused on the basal forebrain's cholinergic system,

The basolateral amygdala (BLA) regulates emotional behavior and reactions and its hyperexcitability is closely related to anxiety and fear. Given that selective degeneration of local GABAergic interneurons could lead to increased anxiety-like behavior, our aim was to test the efficacy of commercially available saporin-anti-vesicular GABA transporter conjugates (SAVA) and their ability to alter the parameters of anxiety-like behavior. For this purpose, adult male Wistar rats were divided into three experimental groups treated with different SAVA doses (20, 40 and 80 ng per injection site, 6 ani