An innovative strategy to identify new chemical classes of GABAA α5 receptor modulators
Nadia von Schoubye, Tino Dyhring, Janus Larsen, Karin Sandager Nielsen, Florian Montel, Oliver Hucke · FENS Forum 2024
Type A γ-aminobutyric acid (GABAA) receptors are pentameric ligand-gated chloride channels and serves as the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system. 1,2 Dysfunction of GABAA receptors is implicated in a range of neurological disorders, including schizophrenia, autism, and epilepsy3,4,5.We’re presenting the building of in silico models based on a comprehensive and high-quality dataset set generated by Saniona A/S, Denmark. These models were utilized in an innovative computational and medicinal chemistry strategy. This novel approach allowed a drastic
ePoster · Neuroscience