Topic: In vivo two-photon microscopy

Animals must infer the three-dimensional structure of the surrounding world from two-dimensional images on their retinas. For instance, animals use visual cues like motion parallax and binocular disparity to judge distances to objects as they navigate their environment. Although studies in several vision models have found neural activity that correlates with distance signals, the causal behavioral role of neurons and the range of possible properties that inform distance perception have remained poorly understood. Here, we developed a novel high-throughput behavioral assay to identify neurons i

Strategy updating is one of the recent roles assigned to the retrosplenial cortex (RSC). Studies have shown that lesions or inactivation of RSC cause impairment in exploring and learning new alternative options when previous ones were available but no longer appropriate, suggesting its importance for set-shifting behaviors1. Building on previous evidence of impaired reversal learning in 6-month-old 5xFAD mice2, this study focuses on uncovering the synaptic correlates of reversal learning in the RSC in the context of AD. Therefore, we use a set-shifting task that challenges the animals to devel