Topic: Individual behavioral profiling

Dietary restriction (DR), has been shown to improve brain health and function, partly by enhancing GABAergic function and improving the excitation-inhibition balance. However, very few neuro-behavioral studies have explored the beneficial effects of DR outside models of age-related neuropathologies. Therefore, here, we set out to explore DR's-therapeutic potential for stress-induced psychopathologies, by utilizing the "Individual behavioral profiling" approach. Towards that end, after exposing the animals to stress, an “individual Behavioral Profiling” analysis was used to identify, prior to t

The first-line pharmacological treatments for PTSD patients are serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). However, both treatments achieve full recovery in fewer than 30% of patients, underscoring the variability in responsiveness among individuals. To this day, there is a profound lack of knowledge regarding the neural mechanisms underlying responsiveness to these treatments. In our study, employing a male rat model of PTSD, we utilized individual behavioral profiling (IBP) following comprehensive behavioral assessments to distinguish between trauma-affected