Inflammation

…programme within a centre studying inflammation, angiogenesis, metabolism, genetic and epigenetic regulation, and tumour immunity. The scientific focus connects mechanisms of cancer initiation, progression and metastasis with the tumour microenvironment and their potential therapeutic implications. Applicants submit their research vision and supporting academic material

…centre spanning angiogenesis, inflammation, metabolism, genetic and epigenetic regulation, and cancer immunology. The research objective is to clarify mechanisms of tumour initiation, progression and metastatic dissemination and connect fundamental findings with therapeutic development. The employer provides a role-specific online applicat

…neuroimmune communication, including inflammation and increased monocyte abundance. It connects these mechanisms with translational efforts to develop targeted interventions for major depression and post-traumatic stress disorder.

…cellular aging, immune activation, inflammation and microbiome interactions with injury in the liver, gut, brain and cardiovascular system and with cancer. Organoids and other experimental platforms support discussion of therapeutic strategies, alongside integrated treatment of alcohol use disorder and end-organ damage. Talks, poster sessions and discussion focus on emerging and unpublished research. Applicants need a science or engineering bachelor’s degree or equivalen

…cell-cycle control, marrow support, inflammation, metabolic regulation and cellular memory to altered self-renewal and blood-cell production. It also considers genomic instability, clonal hematopoiesis and progression toward leukemia.

…and responses to infection and inflammation.

Stress and sleep disruption promote inflammation and metabolic adaptations, with important disease-modifying implications for psychiatric disorders. Using a novel chronic unpredictable sleep disruption (CUSD) paradigm, we characterised the impact of disrupted sleep and/or stress hormone exposure on locomotor behaviour and central markers of inflammation in the nucleus accumbens (NAc), a region implicated in regulation of mood, motivation and locomotor activity. Forty-eight Wistar rats (24 male; 24 female) were separated into groups exposed to combinations of CUSD/non-CUSD and corticosterone (2

The choroid plexus (ChP) is a highly vascularized non-neural tissue located in the brain ventricles and is responsible for the production of a large part of the cerebrospinal fluid (CSF). In addition, the epithelial cells of the ChP synthesize neurotrophic factors and other signalling molecules into CSF and act as a blood-cerebrospinal fluid barrier. Importantly, ChP cells harbour a robust circadian oscillator that may control ChP function and may play an important role in the circuitry between brain clocks. In this study, we aimed to find out whether the ChP clock is sensitive to a robust imm

The migratory dynamics of macrophages are pivotal in orchestrating inflammation and the progression of pathological states. This study delves into the therapeutic promise of morin hydrate (MH), a bioflavonoid ubiquitously present in diverse botanical sources, aiming to assuage inflammation through the nuanced inhibition of macrophage migration. Employing the LPS-stimulated RAW264.7 cell line, the specific molecular mechanisms underpinning MH's anti-inflammatory prowess are scrutinized. The findings unveil that MH manifests concentration-dependent anti-inflammatory effects, intricately curtaili

Recent research highlights inflammation's pivotal role in the etiology of psychotic disorders, emphasizing the potential of inflammatory markers as diagnostic and prognostic tools. This study aimed to elucidate the differential profiles of neutrophil-to-lymphocyte ratio(NLR), monocyte-to-lymphocyte ratio(MLR), platelet-to-lymphocyte ratio(PLR), and systemic immune-inflammatory index(SII) in schizophrenia versus acute psychosis. Conducting a retrospective analysis, we included 126 patients from Prof. Dr. Alexandru Obregia Hospital in Bucharest, divided into two cohorts: 67 patients diagnosed wi

…of secondary injuries, involving inflammation, cell death, demyelination, and scar formation. How the individual types and subtypes of cells of the central nervous system coordinate to mediate this response remains unclear. While much of our current knowledge is derived from rodents, therapies effective in these models have not translated successfully to clinical trials. Understanding molecular responses across species—lower vertebrates, non-primate mammals, and primates—is crucial for formulating effective human treatments. We aim to u

…of oxidative stress (OS) and inflammation.Therefore, the aim of this work was to evaluate whether the modulation of p75NTR by LM11A-31 counteracts the alterations in OS and

…in preventing oxidative stress and inflammation. In the brain, Nrf2 is highly expressed by endothelial cells. Brain endothelial cells (BECs) are the key component of the blood brain barrier (BBB), which controls brain homeostasis. The role of BEC Nrf2 expression in maintaining homeostasis is not fully understood. In this project, through gain- and loss function experiments, we have found that Nrf2 activity in BEC

…promotes vascular damage, inflammation, and thrombosis. We hypothesize that prolonged PK activation determines stroke severity and impairs tissue recovery. Thus, wild-type mice were subjected to 60 mi

Tissue plasminogen activator (tPA) is a protease expressed in CNS by various cells and it is mainly known for its thrombolytic function in the treatment of stroke. While its contribution to myelination within the central nervous system is known, its involvement in peripheral remyelination processes remains to be explored. Indeed, in physiological conditions, Schwann cells, responsible for myelination, express low levels of tPA, however its expression increases following injuries to peripheral nerves. Therefore, our study focused on elucidating involvement of tPA in peripheral nervous system re

The Transient receptor Receptor potential Potential melastatin Melastatin family member subtype 8 (TRPM8) receptor-channel is involved in mammalian innocuous cold perception and is also known to mediate anti-inflammatory effects, reversing nociceptive hypersensitivity and reducing chronic pain. Besides the well-characterized effects of prostacyclin (PGI2) in the vasculature, there is a general recognition that PGI2 is also involved in nociception, as it induces pain sensitivity and increase inflammatory responses. These biological effects are mediated by the prostacyclin receptor (IP-R) expres

…courses with both demyelination and inflammation. We used two different animal models to recapitulate different aspects of this disease, experimental autoimmune encephalomyelitis (EAE) and cuprizone (CPZ) induced demyelination. To study the differential response of the CNS, we compared the proteomic profile of EAE mice (at peak disease) and CPZ mice (in the acute phase) in two different CNS regions: somatosensorial cortex (Cx) and spinal cord (SC). Our resul

…synaptic homeostasis, inflammation, blood-brain

…has emphasized the critical role of inflammation in the pathophysiological processes implicated in a large spectrum o

Cancer-related fatigue is a prominent and debilitating side effect of cancer and its treatment. It can develop prior to diagnosis, generally peaks during cancer treatment, and can persist long after treatment completion. Its mechanisms are multifactorial, and its expression is highly variable. Unfortunately, treatment options are limited. Our research uses syngeneic murine models of cancer and cisplatin-based chemotherapy to better understand these mechanisms. Our data indicate that both peripherally and centrally processes may contribute to the developmental of fatigue. These processes includ

…data on the role of stress-induced inflammation in reward-related psychological processes. Finally, I will discuss the biobehavioral predictors of first-onset depression

…Failure of inflammation to resolve is a key underlying reason of poor regeneration, and one focus is therefore on the biology of microglia during de- and re

…supply to the brain, but also involves inflammation that may cause chronic damage

…progression, abrogating persistent CNS inflammation, and support degenerating axons in people with progressive MS. Understanding why regeneration fails in the progressive MS brain and developing new regenerative approaches is a key priority for the Pluchino Lab. In particular, we aim to elucidate how the immune system, i