Topic: inflammatory mediators

Several adverse intrauterine conditions during pregnancy may increase the risk of neurodevelopmental disorders, including Autism Spectrum Disorder (ASD). Endogenous retroviruses (ERVs) have been proposed as co-factors in the pathogenesis of ASD, also potentially useful as early biomarkers of derailed neurodevelopment. Two preclinical models of ASD, the inbred BTBR T+tf/J (BTBR) mice, and mice prenatally exposed to valproic acid, showed an altered expression of several ERVs and cytokines, in embryos, blood and brain samples at different post-natal ages. The present study aimed to characterize t

Huntington’s disease (HD) is a genetic neurodegenerative disorder that can result in motor, mood and cognitive symptoms. HD pathophysiology has been linked to neuroinflammation, which is the presence of inflammatory mediators and reactive glial cells in the brain parenchyma. Many signalling pathways likely interact to propagate neuroinflammation and contribute to cell loss. Previous literature indicates that in the anterior cingulate cortex, cell loss and neuroinflammation are correlated with HD mood symptoms. This project gives insight into inflammation-related differential gene expression in