ipRGCs

…photosensitive retinal ganglion cells (ipRGCs), a type of neuron in the retinal of mammalian eyes, by releasing glutamate. The innervation of ipRGCs to SCN has been revealed by using genetic tracing techniques and contributes to the synchronization of the circadian rhythm. SCN is a heterogenous structure that contains different neurons, while AVP and VIP neurons are critical for the networking of circadian rhythm.

…photosensitive retinal ganglion cells (ipRGCs). These are a unique type of retinal ganglion cell that contains the photopigment melanopsin. ipRGCs are the retinal neurons responsible for driving non-imaging forming behaviors and reflexes, such as circadian entrainment and pupil constriction, amongst many others. My lab has recently focused on uncovering the diversity of ipRGCs, their distribution throughout the mammalian retina, and their axon projections in the brain.

…photosensitive retinal ganglion cells (ipRGCs) 20 years ago, considerable progress has been made in understanding melanopsin's contributions to encoding irradiance. Much less is known about the cone inputs to ipRGCs and how they could encode changes in the color of the sky. I will summarize our recent connectomic investigation into the cone-opponent inputs to primate ipRGCs and the implications of this work on our understanding of cir

Since the discovery of the intrinsically photosensitive retinal ganglion cells (ipRGCs) – just two decades ago – substantial work has been carried out trying to understand their functioning. In this seminar, I’ll focus on pupillometry studies that have provided key clues about ipRGC behavior. Specifically, the interaction between the intrinsic response, rods, and cones will be discussed.

…photosensitive retinal ganglion cells (ipRGCs). I will discuss our lab’s recent work uncovering a new inhibitory signaling pathway from the eye to the brain that dampens the sensitivity of our circadian and pupil systems to light.