ePoster · Computational Neuroscience
Integrating activity measurements into connectome-constrained and task-optimized models
Linda Ulmer, Janne Lappalainen, Srinivas Turaga, Jakob Macke · Bernstein Conference 2024
The brain of the fruit fly is well suited to study general principles of brain function, because it is small enough to be studied at the single-cell level and its connectivity is well known. This makes it possible to build mechanistic models with the same connectivity as the fruit fly brain, and to train them on tasks in order to constrain the free model parameters. It has recently been shown that such connectome-constrained ‘deep mechanistic network’ models (DMNs), when task-optimized to perform motion detection, can predict the tuning of single-cells in the fruit fly visual system and ca