Kv1.1

Automated voltage-clamp recordings from 40 voltage-gated potassium (Kv) channels [1] revealed the inherent kinetic heterogeneity of some Kv types expressed in the brain (e.g. Kv1.3). A model capable of capturing the kinetic Kv heterogeneity requires both fixed model features shared between cells, and the ability to capture the variability present in individual cells. The classical Hodgkin Huxley (HH) formalism [2], by itself, does not possess these properties. We apply the Deep Non-Linear Mixed Effects (DeepNLME) framework [3] to model the kinetic Kv heterogeneity. DeepNLME combines deep lea

The functioning of a synapse depends on its accessibility to proteins and, thus, on the localization of protein sources along the dendrite (Westenbroek 2009, Vacher et al. 2008). Therefore, the behaviour of the synapse highly depends on the availability of proteins and ion channels and any perturbation in the localization and availability of these components would lead to a dysfunction of the synapse. Hence, understanding the localization and distribution of ion channels and proteins in the dendrite in relation to the synapse is crucial. Using super-resolution microscopy, Helm et al., 2021 der

Loss–of–function mutations in the KCNA1(Kv1.1) gene cause episodic ataxia type 1 (EA1), a severe neurological disease characterized by cerebellar dysfunction, ataxic attacks, persistent myokymia with painful cramps in skeletal muscles and epilepsy. Precision medicine for EA1 treatment is currently unfeasible, as no drug that can enhance the activity of Kv1.1–containing channels and offset the functional defects caused by KCNA1 mutations has been clinically approved. Here we uncovered that niflumic acid (NFA), a currently prescribed analgesic and anti–inflammatory drug with an excellent safety

Autoantibodies (aAb) targeting Contactin-associated protein 2 (Caspr2) have been implicated in neuropathic pain, yet the precise underlying pathomechanism is not completely understood. Caspr2 is part of a protein complex named the voltage-gated potassium channel (VGKC) complex located at the juxtaparanodal region of the nodes of Ranvier in the peripheral nervous system. Dorsal root ganglia (DRG) may serve as mediating neurons transmitting nociceptive signals from the periphery to the central nervous system. Therefore, changes in the excitability of DRG neurons might contribute to the pathology

During Gaze stabilization extraocular muscles produce reflexive compensatory eye movements to fix the image on the retina. Among such a complex sensorimotor transformation the vestibulo-ocular reflexes (VOR), generating compensatory eye movements in response to head motion, require vestibular inputs which are integrated by extraocular motoneurons.In Xenopus larvae, the onset of the angular VOR (aVOR) is delayed compare to other visuo-vestibular reflexes. This delay could imply the existence of distinct parallel pathways in vestibulo-ocular networks, involving distinct motoneuron functional sub